By Greg Geiger
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Additional info for Advances in Bioceramics and Porous Ceramics VI
Fluoride Fluoride has shown to have a positive effect on osteoblast growth and differentiation. 5-lmM has been shown to decrease the résorption of individual osteoclasts, and the résorption was increased by increased concentration of F [30, 31]. Fluoride has shown to induce bone formation in a dos dependent manner at low concentrations , however at high concentrations an inhibitory effect on osteoblast-like cells was observed . Lee et al reported that incorporating F into HA is suitable for clinical applications due to improved long-term stability and improved cell attachment compared to pure HA .
Pak, K. Sakhaee, J. Zerwekh, C. Parcel, R. Peterson, and K. Johnson, Safe and effective treatment of osteoporosis with slow-release sodium fluoride; augmentation of vertebral mass and inhibition of fractures. J Clin Endocrino! Metab, 68: 150-9 (1989). A. El-Ghannam, P. Ducheyne, and I. Shapiro, Porous bioactive glass and hydroxyapaite ceramic affect bone cell function in vitro along different time lines.. J Biomed Mater Res B, 36: 167-80 (1997). H. Lee, Y. Jeong, S. Park, S. Jeong, H. Kim, and C.
Ripamonti, and N. Roveri, Magnesium and strontium interaction with carbonate-containing hydroxyapatite in aqueous medium JInorg Biochem, 15: 317-27 (1981). A. Oliveira, R. Reis, and P. Li, Strontium-substituted apatite coating grown on TÌ6A14V substrate through biomimetic synthesis JBiomed Mater Res B, 83(1): 258-65 (2007). M. Vallet-Regi and A. Daniel, Silicon substituted hydroxyapatites. A method to upgrade calcium phosphate based implants. J Mater Chem, 15: 1509-16 (2005). J. Christoffersen, MR.
Advances in Bioceramics and Porous Ceramics VI by Greg Geiger