John J. Langone (Eds.)'s Antibodies, Antigens, and Molecular Mimicry PDF

By John J. Langone (Eds.)

ISBN-10: 0121820793

ISBN-13: 9780121820794

The seriously acclaimed laboratory regular, Methods in Enzymology, is without doubt one of the so much hugely revered courses within the box of biochemistry. considering 1955, each one quantity has been eagerly awaited, usually consulted, and praised via researchers and reviewers alike. The sequence comprises a lot fabric nonetheless appropriate this day - really a vital e-book for researchers in all fields of existence sciences

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112 Receptors for different endocrine hormones, neurotransmitters, neuropeptides, growth factors, etc. have been subjected to investigation using anti-idiotypic antibodies as probes. The concept of molecular mimicry has particularly drawn the attention of receptor biochemists, as these anti-idiotype molecules serve as useful tools in purification and characterization of receptors that are scantily expressed on the surface of cells. Interactions of idiotypic ligands with receptors for catecholamine hormones, 113-115thyroid-stimulating hormones, ~16acetylcholine, 117 insulin, t~8 lymphokines, 119 etc.

G. Fathelbab, and D. Walker, J. lmmunol. 137, 2339 (1986). [1] IDIOTYPIC NETWORKS AND MOLECULAR MIMICRY 15 Abl in sera from actively infected mice. Therefore, it was concluded that idiotypic or functional components of antibody structure play a role in inducing resistance. Furthermore, the authors emphasized that epitopic specificity is inadequate in determining protective immunity in schistosomiasis and that an idiotypically directed regulatory network may be important in determining the fate of the immune response.

Sachs, J. Exp. Med. 157, 1273 (1983). 96 j. Frelinger, A. Sign, A. Infante, and C. G. Fathman, lmmunol. Rev. 81, 22 (1984). 97 j. S. Kaye, J. Porcelli, J. Tite, B. Jones, and C. A. Janeway, J. Exp. Med. 158, 836 (1983). J. W. Forstrom, K. A. Nelson, G. T. Nepom, I. Hellstr6m, and K. E. Hellstr6m, Nature (London) 303, 627 (1983). 18 IDIOTYPES, ANTI-IDIOTYPES, AND MOLECULAR MIMICRY [1] In another report, Nepom e t al. 2. The polyclonal antisera contained antibodies against binding site-related idiotopes.

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Antibodies, Antigens, and Molecular Mimicry by John J. Langone (Eds.)

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