By Anthony W. H. Chan, Alberto Quaglia, Beate Haugk, Alastair Burt
The liver is a posh organ as a result of its exact microscopic constitution, elaborate metabolic capabilities and susceptibility to a large choice of insults, manifesting in numerous histological patterns. Atlas of Liver Pathology considers either adjustments visible in scientific liver biopsies in addition to lesional biopsies while the specimen has been taken from a mass. The ebook starts off through reviewing common constitution and its versions and the optimum ways for the education of histological sections for diagnostic liver pathology. the subsequent chapters are devoted to developmental, metabolic, infectious, drug similar, autoimmune, biliary, vascular and neoplastic problems. sections on liver pathology in being pregnant and transplantation finish the paintings. Macroscopic illustrations are incorporated the place acceptable. All images are complemented via legends describing the image and offering correct similar information.
Authored through nationally and the world over famous pathologists, Atlas of Liver Pathology is a invaluable source that serves as a brief reference consultant for the prognosis of traditional and strange diseases.
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Extra resources for Atlas of Liver Pathology
Caroli disease sometimes is considered one form (type V) of choledochal cyst; thus, choledochal cyst also is included in this section. The pathogenesis of Caroli disease, congenital hepatic fibrosis, and polycystic liver disease is associated with mutations in genes encoding proteins on primary cilia; hence, fibrocystic liver disease also may be regarded as a ciliopathy. Fig. 7 von Meyenburg complex. Numerous irregularly dilated ductal structures are present in a fibrous stroma and are lined by a single layer of bland cuboidal epithelial cells.
Portal hypertension occurs in Caroli syndrome and usually precedes episodes of acute cholangitis. Caroli disease is associated with an overall risk of 7% to 15% for developing cholangiocarcinoma. 2 Fibrocystic Liver Disease and Choledochal Cyst Fig. 20 Caroli disease. A cystically dilated bile duct is eroded and filled with inspissated bile sludge. Caroli disease is characterised by multiple segmental dilatations of the intrahepatic biliary tree. Intraluminal protrusion of the duct wall with a fibrovascular core is a typical finding.
Fig. 36 Microvesicular steatosis (oil red O stain). Multiple minute fat droplets are seen in the hepatocytes. Such fat droplets occasionally are so small that hepatocytes appear swollen with a fine foamy cytoplasm, which may mimic ballooning degeneration, feathery degeneration, and glycogen-rich hepatocytes. Although the oil red O stain can highlight these droplets, it requires a frozen section of the specimen, which usually is not available routinely. Immunostaining for CK8/18 is useful for differentiating ballooning degeneration from microvesicular steatosis by the loss of cytoplasmic expression in the former.
Atlas of Liver Pathology by Anthony W. H. Chan, Alberto Quaglia, Beate Haugk, Alastair Burt